Best Practice & Research Clinical Anaesthesiology
Volume 24, Issue 2 , Pages 171-182 , June 2010

New insights into experimental evidence on atelectasis and causes of lung injury

  • Thomas Muders, MD (Staff Anaesthesiologist)
    • ,
  • Hermann Wrigge, MD, PhD (Associate Professor of Anaesthesiology and Intensive Care Medicine)

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +49 228 287 14112; Fax: +49 228 287 14125.

References 

  1. Froese AB, Bryan AC. Effects of anesthesia and paralysis on diaphragmatic mechanics in man. Anesthesiology. 1974;41:242–255
  2. Kleinman BS, Frey K, VanDrunen M, et al. Motion of the diaphragm in patients with chronic obstructive pulmonary disease while spontaneously breathing versus during positive pressure breathing after anesthesia and neuromuscular blockade. Anesthesiology. 2002;97:298–305
  3. Hedenstierna G, Santesson J. Airway closure and distribution of inspired gas in the extremely obese, breathing spontaneously and during anaesthesia with intermittent positive pressure ventilation. Acta Anaesthesiologica Scandinavica. 1976;20:334–342
  4. Rehder K, Sessler AD. Regional intrapulmonary gas distribution in awake and anesthetized-paralyzed man. Journal of Applied Physiology. 1977;42:391–402
  5. Manzano F, Fernandez-Mondejar E, Colmenero M, et al. Positive-end expiratory pressure reduces incidence of ventilator-associated pneumonia in nonhypoxemic patients. Critical Care Medicine. 2008;36:2225–2231
  6. Lin CY, Zhang H, Cheng KC, Slutsky AS. Mechanical ventilation may increase susceptibility to the development of bacteremia. Critical Care Medicine. 2003;31:1429–1434
  7. Verbrugge SJ, Sorm V, van 't Veen A, et al. Lung overinflation without positive end-expiratory pressure promotes bacteremia after experimental Klebsiella pneumoniae inoculation. Intensive Care Medicine. 1998;24:172–177
  8. Fels AO, Cohn ZA. The alveolar macrophage. Journal of Applied Physiology. 1986;60:353–369
  9. Broug-Holub E, Toews GB, van Iwaarden JF, et al. Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival. Infection and Immunity. 1997;65:1139–1146
  10. Shennib H, Mulder DS, Chiu RC. The effects of pulmonary atelectasis and reexpansion on lung cellular immune defenses. Archives of Surgery. 1984;119:274–277
  11. LaForce FM, Mullane JF, Boehme RF, et al. The effect of pulmonary edema on antibacterial defenses of the lung. The Journal of Laboratory and Clinical Medicine. 1973;82:634–648
  12. Nizet V, Gibson RL, Chi EY, et al. Group B streptococcal beta-hemolysin expression is associated with injury of lung epithelial cells. Infection and Immunity. 1996;64:3818–3826
  13. Pison U, Max M, Neuendank A, et al. Host defence capacities of pulmonary surfactant: evidence for ‘non-surfactant’ functions of the surfactant system. European Journal of Clinical Investigation. 1994;24:586–599
  14. Takahashi H, Sano H, Chiba H, Kuroki Y. Pulmonary surfactant proteins A and D: innate immune functions and biomarkers for lung diseases. Current Pharmaceutical Design. 2006;12:589–598
  15. Kuroki Y, Takahashi M, Nishitani C. Pulmonary collectins in innate immunity of the lung. Cellular Microbiology. 2007;9:1871–1879
  16. van Kaam AH, Lachmann RA, Herting E, et al. Reducing atelectasis attenuates bacterial growth and translocation in experimental pneumonia. American Journal of Respiratory and Critical Care Medicine. 2004;169:1046–1053
  17. Madjdpour C, Jewell UR, Kneller S, et al. Decreased alveolar oxygen induces lung inflammation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2003;284:L360–L367
  18. Duggan M, McCaul CL, McNamara PJ, et al. Atelectasis causes vascular leak and lethal right ventricular failure in uninjured rat lungs. American Journal of Respiratory and Critical Care Medicine. 2003;167:1633–1640
  19. Duggan M, McNamara PJ, Engelberts D, et al. Oxygen attenuates atelectasis-induced injury in the in vivo rat lung. Anesthesiology. 2005;103:522–531
  20. Matute-Bello G, Frevert CW, Martin TR. Animal models of acute lung injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2008;295:L379–L399
  21. Zaher TE, Miller EJ, Morrow DM, et al. Hyperoxia-induced signal transduction pathways in pulmonary epithelial cells. Free Radical Biology & Medicine. 2007;42:897–908
  22. Carney D, DiRocco J, Nieman G. Dynamic alveolar mechanics and ventilator-induced lung injury. Critical Care Medicine. 2005;33:S122–S128
  23. Dunnill MS. Effect of lung inflation on alveolar surface area in the dog. Nature. 1967;214:1013–1014
  24. Escolar JD, Escolar MA, Guzman J, Roques M. Pressure volume curve and alveolar recruitment/de-recruitment. A morphometric model of the respiratory cycle. Histology and Histopathology. 2002;17:383–392
  25. Smaldone GC, Mitzner W, Itoh H. Role of alveolar recruitment in lung inflation: influence on pressure-volume hysteresis. Journal of Applied Physiology. 1983;55:1321–1332
  26. Gatto LA, Fluck RR. Alveolar mechanics in the acutely injured lung: role of alveolar instability in the pathogenesis of ventilator-induced lung injury. Respiratory Care. 2004;49:1045–1055
  27. Crotti S, Mascheroni D, Caironi P, et al. Recruitment and derecruitment during acute respiratory failure: a clinical study. American Journal of Respiratory and Critical Care Medicine. 2001;164:131–140
  28. Pelosi P, D’Andrea L, Vitale G, et al. Vertical gradient of regional lung inflation in adult respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine. 1994;149:8–13
  29. Gaver DP, Kute SM. A theoretical model study of the influence of fluid stresses on a cell adhering to a microchannel wall. Biophysical Journal. 1998;75:721–733
  30. International consensus conferences in intensive care medicine. Ventilator-associated lung injury in ARDS. American Thoracic Society, European Society of Intensive Care Medicine, Societe de Reanimation Langue Francaise. Intensive Care Medicine. 1999;25:1444–1452
  31. Steinberg JM, Schiller HJ, Halter JM, et al. Alveolar instability causes early ventilator-induced lung injury independent of neutrophils. American Journal of Respiratory and Critical Care Medicine. 2004;169:57–63
  32. Mead J, Takishima T, Leith D. Stress distribution in lungs: a model of pulmonary elasticity. Journal of Applied Physiology. 1970;28:596–608
  33. Tsuchida S, Engelberts D, Peltekova V, et al. Atelectasis causes alveolar injury in nonatelectatic lung regions. American Journal of Respiratory and Critical Care Medicine. 2006;174:279–289
  34. Hubmayr RD. Perspective on lung injury and recruitment: a skeptical look at the opening and collapse story. American Journal of Respiratory and Critical Care Medicine. 2002;165:1647–1653
  35. Kamm RD, Schroter RC. Is airway closure caused by a liquid film instability?. Respiration Physiology. 1989;75:141–156
  36. Hubmayr RD. Another look at the opening and collapse story. Critical Care Medicine. 2009;37:2667–2668
  37. Rouby JJ, Puybasset L, Nieszkowska A, Lu Q. Acute respiratory distress syndrome: lessons from computed tomography of the whole lung. Critical Care Medicine. 2003;31:S285–S295
  38. Huh D, Fujioka H, Tung YC, et al. Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems. Proceedings of the National Academy of Sciences of the United States of America. 2007;104:18886–18891
  39. Bilek AM, Dee KC, Gaver DP. Mechanisms of surface-tension-induced epithelial cell damage in a model of pulmonary airway reopening. Journal of Applied Physiology. 2003;94:770–783
  40. Mertens M, Tabuchi A, Meissner S, et al. Alveolar dynamics in acute lung injury: heterogeneous distension rather than cyclic opening and collapse. Critical Care Medicine. 2009;37:2604–2611
  41. Gattinoni L, Caironi P, Cressoni M, et al. Lung recruitment in patients with the acute respiratory distress syndrome. The New England Journal of Medicine. 2006;354:1775–1786
  42. Caironi P, Cressoni M, Chiumello D, et al. Lung opening and closing during ventilation of acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine. 2009;
  43. Gattinoni L, Pelosi P, Suter PM, et al. Acute respiratory distress syndrome caused by pulmonary and extrapulmonary disease. Different syndromes?. American Journal of Respiratory and Critical Care Medicine. 1998;158:3–11
  44. Gattinoni L, Carlesso E, Cadringher P, et al. Physical and biological triggers of ventilator-induced lung injury and its prevention. The European Respiratory Journal. Supplement. 2003;47:15s–25s
  45. Chiumello D, Carlesso E, Cadringher P, et al. Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine. 2008;178:346–355
  46. Iba T, Maitz S, Furbert T, et al. Effect of cyclic stretch on endothelial cells from different vascular beds. Circulatory Shock. 1991;35:193–198
  47. Meffert M, Hanninen EL, Menzel T, et al. In vivo time and dose dependency of interleukin-6 secretion in response to low-dose subcutaneous recombinant interleukin-2. Cancer Biotherapy. 1994;9:307–316
  48. Pugin J, Dunn I, Jolliet P, et al. Activation of human macrophages by mechanical ventilation in vitro. The American Journal of Physiology. 1998;275:L1040–L1050
  49. van DM, Twickler TB, de Waal Malefyt MC, et al. Elective orthopedic surgery, a model for the study of cytokine activation and regulation. Cytokine. 1998;10:897–903
  50. Vlahakis NE, Hubmayr RD. Response of alveolar cells to mechanical stress. Current Opinion in Critical Care. 2003;9:2–8
  51. Goodman RB, Strieter RM, Martin DP, et al. Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine. 1996;154:602–611
  52. Meduri GU, Headley S, Kohler G, et al. Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time. Chest. 1995;107:1062–1073
  53. Meduri GU, Kohler G, Headley S, et al. Inflammatory cytokines in the BAL of patients with ARDS. Persistent elevation over time predicts poor outcome. Chest. 1995;108:1303–1314
  54. Suter PM, Suter S, Girardin E, et al. High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis. The American Review of Respiratory Disease. 1992;145:1016–1022
  55. Kotani N, Takahashi S, Sessler DI, et al. Volatile anesthetics augment expression of proinflammatory cytokines in rat alveolar macrophages during mechanical ventilation. Anesthesiology. 1999;91:187–197
  56. Ranieri VM, Suter PM, Tortorella C, et al. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. The Journal of the American Medical Association. 1999;282:54–61
  57. Tremblay L, Valenza F, Ribeiro SP, et al. Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. The Journal of Clinical Investigation. 1997;99:944–952
  58. von-Bethmann AN, Brasch F, Nusing R, et al. Hyperventilation induces release of cytokines from perfused mouse lung. American Journal of Respiratory and Critical Care Medicine. 1998;157:263–272
  59. Ricard JD, Dreyfuss D, Saumon G. Production of inflammatory cytokines in ventilator-induced lung injury: a reappraisal. American Journal of Respiratory and Critical Care Medicine. 2001;163:1176–1180
  60. Putensen C, Wrigge H. Ventilator-associated systemic inflammation in acute lung injury. Intensive Care Medicine. 2000;26:1411–1413
  61. Uhlig S. Ventilation-induced lung injury and mechanotransduction: stretching it too far?. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2002;282:L892–L896
  62. Fine A, Janssen-Heininger Y, Soultanakis RP, et al. Apoptosis in lung pathophysiology. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2000;279:L423–L427
  63. Imai Y, Parodo J, Kajikawa O, et al. Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. The Journal of the American Medical Association. 2003;289:2104–2112
  64. Lucas R, Verin AD, Black SM, Catravas JD. Regulators of endothelial and epithelial barrier integrity and function in acute lung injury. Biochemical Pharmacology. 2009;77:1763–1772
  65. Chopra M, Reuben JS, Sharma AC. Acute lung injury:apoptosis and signaling mechanisms. Experimental Biology and Medicine (Maywood, N.J.). 2009;234:361–371
  66. Slutsky AS, Hudson LD. PEEP or no PEEP – lung recruitment may be the solution. The New England Journal of Medicine. 2006;354:1839–1841
  67. Fanelli V, Mascia L, Puntorieri V, et al. Pulmonary atelectasis during low stretch ventilation: “open lung” versus “lung rest” strategy. Critical Care Medicine. 2009;37:1046–1053
  68. Abraham E. Neutrophils and acute lung injury. Critical Care Medicine. 2003;31:S195–S199
  69. Lomas JL, Chung CS, Grutkoski PS, et al. Differential effects of macrophage inflammatory chemokine-2 and keratinocyte-derived chemokine on hemorrhage-induced neutrophil priming for lung inflammation: assessment by adoptive cells transfer in mice. Shock. 2003;19:358–365
  70. Fialkow L, Fochesatto FL, Bozzetti MC, et al. Neutrophil apoptosis: a marker of disease severity in sepsis and sepsis-induced acute respiratory distress syndrome. Critical Care (London, England). 2006;10:R155
  71. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. The New England Journal of Medicine. 2000 May 4;342(18):1301–1308
  72. Stuber F, Wrigge H, Schroeder S, et al. Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury. Intensive Care Medicine. 2002;28:834–841
  73. Nahum A, Hoyt J, Schmitz L, et al. Effect of mechanical ventilation strategy on dissemination of intratracheally instilled Escherichia coli in dogs. Critical Care Medicine. 1997;25:1733–1743
  74. Rello J, Mirelis B, Alonso C, Prats G. Lack of usefulness of blood cultures to diagnose ventilator-associated pneumonia. The European Respiratory Journal. 1991;4:1020
  75. Murphy DB, Cregg N, Tremblay L, et al. Adverse ventilatory strategy causes pulmonary-to-systemic translocation of endotoxin. American Journal of Respiratory and Critical Care Medicine. 2000;162:27–33
  76. Haitsma JJ, Uhlig S, Goggel R, et al. Ventilator-induced lung injury leads to loss of alveolar and systemic compartmentalization of tumor necrosis factor-alpha. Intensive Care Medicine. 2000;26:1515–1522
  77. Dreyfuss D, Saumon G. Ventilator-induced lung injury: lessons from experimental studies. American Journal of Respiratory and Critical Care Medicine. 1998;157:294–323
  78. Held HD, Boettcher S, Hamann L, Uhlig S. Ventilation-induced chemokine and cytokine release is associated with activation of nuclear factor-kappaB and is blocked by steroids. American Journal of Respiratory and Critical Care Medicine. 2001;163:711–716
  79. Tschumperlin DJ, Dai G, Maly IV, et al. Mechanotransduction through growth-factor shedding into the extracellular space. Nature. 2004;429:83–86
  80. Dolinay T, Kaminski N, Felgendreher M, et al. Gene expression profiling of target genes in ventilator-induced lung injury. Physiol Genomics. 2006;26:68–75
  81. Barer GR, Howard P, McCurrie JR, Shaw JW. Changes in the pulmonary circulation after bronchial occlusion in anesthetized dogs and cats. Circulation Research. 1969;25:747–764
  82. Zapol WM, Snider MT. Pulmonary hypertension in severe acute respiratory failure. The New England Journal of Medicine. 1977;296:476–480
  83. Marshall BE, Marshall C, Magno M, et al. Influence of bronchial arterial PO2 on pulmonary vascular resistance. Journal of Applied Physiology. 1991;70:405–415
  84. Mazzone RW. Influence of vascular and transpulmonary pressures on the functional morphology of the pulmonary microcirculation. Microvascular Research. 1980;20:295–306
  85. Carpenter TC, Stenmark KR. Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2001;281:L941–L948
  86. Blagg BS, Kerr TD. Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation. Medicinal Research Reviews. 2006;26:310–338

PII: S1521-6896(10)00026-1

doi: 10.1016/j.bpa.2010.02.009

Best Practice & Research Clinical Anaesthesiology
Volume 24, Issue 2 , Pages 171-182 , June 2010

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