Best Practice & Research Clinical Anaesthesiology
Volume 24, Issue 1 , Pages 27-40 , March 2010

Perioperative coagulation monitoring

  • Sibylle A. Kozek-Langenecker, MBA (Dr. Prof)

      Affiliations

    • Department of Anaesthesiology, General Intensive Care und Pain Management, Vienna Medical University, Währinger Gürtel 18-20, 1090 Vienna, Austria
    • Department of Anaesthesia and Intensive Care, Evangelisches Krankenhaus Wien, Hans Sachs-Gasse 10-12, 1180 Vienna, Austria
    • Corresponding Author InformationDepartment of Anaesthesiology, General Intensive Care und Pain Management, Vienna Medical University, Währinger Gürtel 18-20, 1090 Vienna, Austria. Tel.: +43 1 40400 4144; Fax: +43 1 40400 4165.

References 

  1. Kaplan E, Sheiner L, Boeckmann A, et al. The usefulness of preoperative laboratory screening. The Journal of the American Medical Association. 1985;253:3576–3581
  2. Dzik W. Predicting hemorrhage using preoperative coagulation screening assays. Current Hematology Reports. 2004;3:324–330
  3. Velanovich V. The value of routine preoperative laboratory testing in predicting postoperative complications: a multivariate analysis. Surgery. 1991;109:106–108
  4. Macpherson C, Jacobs P, Dent D. Abnormal peri-operative haemorrhage in asymptomatic patients is not predicted by laboratory testing. South African Medical Journal. 1993;83:106–108
  5. Practice guidelines for perioperative blood transfusion and adjuvant therapies. An updated report by the American Society of anesthesiologists task force on perioperative blood transfusion and adjuvant therapies. Anesthesiology. 2006;105:198–208
  6. Koscielny J, von Tempelhoff GF, Ziemer S, et al. A practical concept for preoperative management of patients with impaired primary hemostasis. Clinical and Applied Thrombosis/Hemostasis. 2004;10:155–166
  7. Pfanner G, Koscielny J, Pernerstorfer T, et al. Preoperative evaluation of the bleeding history. Recommendations of the working group on perioperative coagulation of the Austrian Society for anaesthesia, resuscitation and intensive care. Anaesthesist. 2007;56:604–611
  8. OEGARI. http://www.oegari.at/dateiarchiv/116/bleeding%20history.pdf.
  9. Eberl W, Wendt I, Schroeder H. Preoperative coagulation screening prior to adenoidectomy and tonsillectomy. Klinische Pädiatrie. 2005;217:20–24
  10. Kozek-Langenecker S. Monitoring of hemostasis in the perioperative setting. In:  Maniatis A,  Hardy J,  Van der Linden P editor. Alternatives to blood transfusion in transfusion medicine. Blackwell Publishing; 2009;
  11. Management Medical Society for Bloodmanagement. http://www.bloodmanagement.org/content/view/65/126/.
  12. The British guideline: , Stainsby D, MacLennan S, Thomas D, Isaac J, Hamilton PJ. Guidelines on the management of massive blood loss. British Journal of Anaesthesia. 2006;135:634–641
  13. Ciavarella D, Reed R, Counts R, et al. Clotting factor levels and the risk of diffuse microvascular bleeding in the massively transfused patient. British Journal of Haematology. 1987;67:365–368
  14. Rahe-Meyer N, Solomon C, Winterhalter M et al. Thromboelastometry-guided administration of fibrinogen concentrate for the treatment of excessive intraoperative bleeding in thoracoabdominal aortic aneurysm surgery. The Journal of thoracic and cardiovascular surgery, in press.
  15. Charbit B, Mandelbrot L, Samain E, et al. The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage. Journal of Thrombosis and Haemostasis. 2007;5:266–273
  16. Ketchum L, Hess JR, Hiippala S. Indications for early fresh frozen plasma, cryoprecipitate, and platelet transfusion in trauma. The Journal of Trauma. 2006;60:S51–S58
  17. Hardy JF, de Moerloose P, Samama CM. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Canadian Journal of Anaesthesia. 2006;53:S40–S58
  18. Kozek-Langenecker S. Monitoring of hemostasis in emergency medicine. In:  Vincent JL editors. Yearbook of intensive care and emergency medicine. Berlin-Heidelberg: Springer Verlag; 2007;p. 847–860
  19. Kozek-Langenecker S. Management of massive operative blood loss. Minerva Anestesiologica. 2007;73:401–415
  20. Fries D. Diagnostik beim Blutungsnotfall. In:  Heindl B editors. Gerinnungsmanagement beim perioperativen Blutungsnotfall. 1st edn.. Bremen: Uni-Med Verlag AG; 2008;p. 60–65
  21. Hiippala S. Dextran and hydroxyethyl starch interfere with fibrinogen assays. Blood Coagulation and Fibrinolysis. 1995;6:743–746
  22. Counts RB, Haisch C, Simon TL, et al. Hemostasis in massively transfused trauma patients. Annals of Surgery. 1979;190:91–99
  23. Yuan S, Ferrell C, Chandler WL. Comparing the prothrombin time INR versus the APTT to evaluate the coagulopathy of acute trauma. Thrombosis Research. 2006;
  24. Aucar JA, Norman P, Whitten E, et al. Intraoperative detection of traumatic coagulopathy using the activated coagulation time. Shock. 2003;19:404–407
  25. MacLeod JB, Lynn M, McKenney MG, et al. Early coagulopathy predicts mortality in trauma. The Journal of Trauma. 2003;55:39–44
  26. Erber WN. Massive blood transfusion in the elective surgical setting. Transfusion and Apheresis Science. 2002;27:83–92
  27. Hiippala ST, Myllyla GJ, Vahtera EM. Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesthesia and Pain Control in Dentistry. 1995;81:360–365
  28. Di Benedetto P, Baciarello M, Cabetti L, et al. Thrombelastography. Present and future perspectives in clinical practice. Minerva Anestesiologica. 2003;69:501–509509–515
  29. Luddington RJ. Thrombelastography/thromboelastometry. Clinical and Laboratory Haematology. 2005;27:81–90
  30. OEGARI. http://www.oegari.at/arbeitsgruppe.asp?id=116.
  31. Mangano DT, Tudor IC, Dietzel C. The risk associated with aprotinin in cardiac surgery. The New England Journal of Medicine. 2006;354:353–365
  32. Kettner S, Kozek S, Groeztner J, et al. Effects of hypothermia on thrombelastography in patients undergoing cardiopulmonary bypass. British Journal of Anaesthesia. 1998;80:313–317
  33. Lang T, Bauters A, Braun SL, et al. Multi-centre investigation on reference ranges for ROTEM thromboelastometry. Blood Coagulation & Fibrinolysis. 2005;16:301–310
  34. Cammerer U, Dietrich W, Rampf T, et al. The predictive value of modified computerized thromboelastography and platelet function analysis for postoperative blood loss in routine cardiac surgery. Anesthesia and Analgesia. 2003;96:51–57table of contents
  35. DeLoughery TG. Coagulation defects in trauma patients: etiology, recognition, and therapy. Critical Care Clinics. 2004;20:13–24
  36. Shore-Lesserson L. Evidence based coagulation monitors: heparin monitoring, thromboelastography, and platelet function. Seminars in Cardiothoracic and Vascular Anesthesia. 2005;9:41–52
  37. Shore-Lesserson L, Manspeizer HE, DePerio M, et al. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesthesia and Analgesia. 1999;88:312–319
  38. Avidan MS, Alcock EL, Da Fonseca J, et al. Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery. British Journal of Anaesthesia. 2004;92:178–186
  39. Royston D, von Kier S. Reduced haemostatic factor transfusion using heparinase-modified thrombelastography during cardiopulmonary bypass. British Journal of Anaesthesia. 2001;86:575–578
  40. Nuttall GA, Oliver WC, Santrach PJ, et al. Efficacy of a simple intraoperative transfusion algorithm for nonerythrocyte component utilization after cardiopulmonary bypass. Anesthesiology. 2001;94:773–781discussion 775A–776A
  41. Spiess BD, Gillies BS, Chandler W, et al. Changes in transfusion therapy and reexploration rate after institution of a blood management program in cardiac surgical patients. Journal of Cardiothoracic and Vascular Anesthesia. 1995;9:168–173
  42. Miller BE, Guzzetta NA, Tosone SR, et al. Rapid evaluation of coagulopathies after cardiopulmonary bypass in children using modified thromboelastography. Anesthesia and Analgesia. 2000;90:1324–1330
  43. Kang Y. Coagulation and liver transplantation: current concepts. Liver Transplantation and Surgery. 1997;3:465–467
  44. Anderson L, Quasim I, Soutar R, et al. An audit of red cell and blood product use after the institution of thromboelastometry in a cardiac intensive care unit. Transfusion Medicine. 2006;16:31–39
  45. Spalding G, Hartrumpf M, Sierig T, et al. Cost reduction of perioperative coagulation management in cardiac surgery: value of “bedside” thrombelastography (ROTEM). European Journal of Cardio-Thoracic Surgery. 2007;31:1052–1057
  46. Kozek-Langenecker S. Marketing eines neuen Behandlungsalgorithmus zur bedarfs-orientierten Gerinnungstherapie bei Operationen Österreichische Gesellschaft für wissenschaftliche Weiterbildung und Fernstudium. Vienna: European Business School for International Management, Mannheim in cooperation with Alba Julia University, Karlsburg; 2009;p. 152
  47. Kozek-Langenecker S. www.perioperativebleeding.org.
  48. Mittermayr M, Margreiter J, Velik-Salchner C, et al. Effects of protamine and heparin can be detected and easily differentiated by modified thrombelastography (Rotem): an in vitro study. British Journal of Anaesthesia. 2005;95:310–316
  49. Merritt JC, Bhatt DL. The efficacy and safety of perioperative antiplatelet therapy. Journal of Thrombosis and Thrombolysis. 2004;17:21–27
  50. Tanaka KA, Szlam F, Kelly AB, et al. Clopidogrel (Plavix) and cardiac surgical patients: implications for platelet function monitoring and postoperative bleeding. Platelets. 2004;15:325–332
  51. Lillicrap D, Nair SC, Srivastava A, et al. Laboratory issues in bleeding disorders. Haemophilia. 2006;12(Suppl. 3):68–75
  52. Rodgers R. Bleeding time tables: a tabular summary of pertinent literature. Seminars in Thrombosis and Hemostasis. 1990;16:21–38
  53. Mannucci PM, Federici AB, Sirchia G. Hemostasis testing during massive blood replacement. A study of 172 cases. Vox Sanguinis. 1982;42:113–123
  54. Escolar G, Cases A, Vinas M, et al. Evaluation of acquired platelet dysfunctions in uremic and cirrhotic patients using the platelet function analyzer (PFA-100): influence of hematocrit elevation. Haematologica. 1999;84:614–619
  55. Barrowcliffe TW, Cattaneo M, Podda GM, et al. New approaches for measuring coagulation. Haemophilia. 2006;12(Suppl. 3):76–81
  56. Wahba A, Sander S, Birnbaum DE. Are in-vitro platelet function tests useful in predicting blood loss following open heart surgery?. The Thoracic and Cardiovascular Surgeon. 1998;46:228–231
  57. Forestier F, Coiffic A, Mouton C, et al. Platelet function point-of-care tests in post-bypass cardiac surgery: are they relevant?. British Journal of Anaesthesia. 2002;89:715–721
  58. Paniccia R, Antonucci E, Maggini N, et al. Assessment of platelet function on whole blood by multiple electrode aggregometry in high-risk patients with coronary artery disease receiving antiplatelet therapy. American Journal of Clinical Pathology. 2009;131:834–842
  59. Sibbing D, Braun S, Jawansky S, et al. Assessment of ADP-induced platelet aggregation with light transmission aggregometry and multiple electrode platelet aggregometry before and after clopidogrel treatment. Thrombosis and Haemostasis. 2008;99:121–126
  60. Jambor C, Weber C, Gerhardt K et al. Whole blood multiple electrode aggregometry is a reliable point-of-care test of aspirin-induced platelet dysfunction. Anesthesia and analgesia, in press.
  61. Velik-Salchner C, Maier S, Innerhofer P, et al. An assessment of cardiopulmonary bypass-induced changes in platelet funtion using whole blood and classical light transmission aggregometry: the results of a pilot study. Anesthesia and Analgesia. 2009;108:1747–1754
  62. Mengistu A, Wolf M, Boldt J, et al. Evaluation of a new platelet function analyzer in cardiac surgery: a comparison of modified thrombelastography and whole-blood aggregometry. Journal of Cardiothoracic and Vascular Anesthesia. 2008;22:40–46

PII: S1521-6896(09)00073-1

doi: 10.1016/j.bpa.2009.09.009

Best Practice & Research Clinical Anaesthesiology
Volume 24, Issue 1 , Pages 27-40 , March 2010

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