Best Practice & Research Clinical Anaesthesiology
Volume 24, Issue 1 , Pages 95-106, March 2010

Activated recombinant factor VII (rFVIIa)

  • Oliver Grottke, MD, MPH (Anaesthesiologist)

      Affiliations

    • Department of Anaesthesiology, Institute for Laboratory Animal Science, RWTH Aachen University Hospital, Pauwelsstrasse 30; D-52074 Aachen, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 241 8080972.
    • ,
  • Dietrich Henzler, MD, PhD FRCPC (Professor of Anaesthesia)

      Affiliations

    • Medicine and Physiology, Dalhousie University Halifax, Queen Elisabeth II Health Sciences Center, Department of Anesthesia and Division of Critical Care, 10 West Victoria, 1276 South Park St., Halifax, NS, B3H 2Y9, Canada
    • ,
  • Rolf Rossaint, MD, PhD (Professor and Chairman)

      Affiliations

    • Department of Anaesthesiology, RWTH Aachen University Hospital, Pauwelsstrasse 30; D-52074 Aachen, Germany

Recombinant activated factor VII (rFVIIa) is a haemostatic agent, which was originally developed for the treatment of haemophilia patients with inhibitors against factor FVIII or FIX. The efficacy of rFVIIa in preventing or stopping life-threatening bleeding for these patients has been demonstrated in several studies. Since the first report about the successful use of rFVIIa in a bleeding soldier in 1999, rFVIIa has gained popularity as an adjunct for the treatment of coagulopathy in a wide array of clinical conditions with serious or life-threatening bleeding. The number of case reports and case series documenting the successful use of rFVIIa as last resort to terminate uncontrollable bleeding has steadily grown.

Conflicting results have been reported from various studies. Considering the lack of data and potential publication bias associated with case reports, this review summarises the clinical evidence of the efficacy and safety of rFVIIa in the perioperative period.

Keywords: recombinant activated factor VIIa, haemorrhage, blood, coagulation trauma, perioperative

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PII: S1521-6896(09)00069-X

doi:10.1016/j.bpa.2009.09.005

Best Practice & Research Clinical Anaesthesiology
Volume 24, Issue 1 , Pages 95-106, March 2010

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