Best Practice & Research Clinical Anaesthesiology
Volume 23, Issue 4 , Pages 441-448 , December 2009

Clinical benefits of tight glycaemic control: Focus on the paediatric patient

  • Ingeborg van den Heuvel, MD (Research Fellow)

      Affiliations

    • Department of Anaesthesiology and Intensive Care Medicine, University Hospital Muenster, Albert-Schweitzer-Strasse 33, 48149, Muenster, Germany
    • Corresponding Author InformationCorresponding author. Department of Anaesthesiology and Intensive Care Medicine, University Hospital Muenster, Albert-Schweitzer-Strasse 33, D-48149 Muenster Germany. Tel.: +49 251 8347252; Fax: +49 251 88704.
    • ,
  • Dirk Vlasselaers, MD, PhD (Consultant PICU)

      Affiliations

    • Department of Intensive Care Medicine, Catholic University Leuven, Herestraat 49, 3000 Leuven, Belgium
    • Tel.: +3216344021; Fax: +3216344015.

References 

  1. Hirshberg E, Lacroix J, Sward K, et al. Blood glucose control in critically ill adults and children: a survey on stated practice. Chest. 2008;133:1328–1335
  2. Nayak P, Lang H, Parslow R, et al. UK Paediatric Intensive Care Society Study Group (PICS SG). Hyperglycemia and insulin therapy in the critically ill child. Pediatric Critical Care Medicine. 2009;10:303–305
  3. Faustino EV, Apkon M. Persistent hyperglycemia in critically ill children. The Journal of Pediatrics. 2005;146:30–34
  4. Wintergerst KA, Deiss D, Buckingham B, et al. Glucose control in pediatric intensive care unit patients using an insulin-glucose algorithm. Diabetes Technology & Therapeutics. 2007;9:211–222
  5. Srinivasan V, Spinella PC, Drott HR, et al. Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children. Pediatric Critical Care Medicine. 2004;5:329–336
  6. Klein GW, Hojsak JM, Schmeidler J, et al. Hyperglycemia and outcome in the pediatric intensive care unit. The Journal of Pediatrics. 2008;153:379–384
  7. Polito A, Thiagarajan RR, Laussen PC, et al. Association between intraoperative and early postoperative glucose levels and adverse outcomes after complex congenital heart surgery. Circulation. 2008;118:2235–2242
  8. Falcao G, Ulate K, Kouzekanani K, et al. Impact of postoperative hyperglycemia following surgical repair of congenital cardiac defects. Pediatric Cardiology. 2008;29:628–636
  9. Yates AR, Dyke PC, Taeed R, et al. Hyperglycemia is a marker for poor outcome in the postoperative pediatric cardiac patient. Pediatric Critical Care Medicine. 2006;7:351–355
  10. Ghafoori AF, Twite MD, Friesen RH. Postoperative hyperglycemia is associated with mediastinitis following pediatric cardiac surgery. Paediatric Anaesthesia. 2008;18:1202–1207
  11. Rossano JW, Taylor MD, Smith EO, et al. Glycemic profile in infants who have undergone the arterial switch operation: hyperglycemia is not associated with adverse events. The Journal of Thoracic and Cardiovascular Surgery. 2008;135:739–745
  12. de Ferranti S, Gauvreau K, Hickey PR, et al. Intraoperative hyperglycemia during infant cardiac surgery is not associated with adverse neurodevelopmental outcomes at 1, 4, and 8 years. Anesthesiology. 2004;100:1345–1352
  13. Heimann K, Peschgens T, Kwiecien R, et al. Are recurrent hyperglycemic episodes and median blood glucose level a prognostic factor for increased morbidity and mortality in premature infants </=1500 g?. Journal of Perinatal Medicine. 2007;35:245–248
  14. Hall NJ, Peters M, Eaton S, et al. Hyperglycemia is associated with increased morbidity and mortality rates in neonates with necrotizing enterocolitis. Journal of Pediatric Surgery. 2004;39:898;901; discussion 898–901
  15. Branco RG, Garcia PC, Piva JP, et al. Glucose level and risk of mortality in pediatric septic shock. Pediatric Critical Care Medicine. 2005;6:470–472
  16. Day KM, Haub N, Betts H, Inward DP. Hyperglycemia is associated with morbidity in critically ill children with meningococcal sepsis. Pediatric Critical Care Medicine. 2008;9:636–640
  17. Gore DC, Chinkes D, Heggers J, et al. Association of hyperglycemia with increased mortality after severe burn injury. The Journal of Trauma. 2001;51:540–544
  18. Chiaretti A, De Benedictis R, Langer A, et al. Prognostic implications of hyperglycaemia in paediatric head injury. Child's Nervous System. 1998;14:455–459
  19. Cochran A, Scaife ER, Hansen KW, Downey EC. Hyperglycemia and outcomes from pediatric traumatic brain injury. The Journal of Trauma. 2003;55:1035–1038
  20. Wintergerst KA, Buckingham B, Gandrud L, et al. Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit. Pediatrics. 2006;118:173–179
  21. Hirshberg E, Larsen G, Van Duker H. Alterations in glucose homeostasis in the pediatric intensive care unit: hyperglycemia and glucose variability are associated with increased mortality and morbidity. Pediatric Critical Care Medicine. 2008;9:361–366
  22. Pham TN, Warren AJ, Phan HH, et al. Impact of tight glycemic control in severely burned children. The Journal of Trauma. 2005;59:1148–1154
  23. Vlasselaers D, Milants I, Desmet L, et al. Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study. Lancet. 2009;373:547–556
  24. Turina M, Fry DE, Polk HC. Acute hyperglycemia and the innate immune system: clinical, cellular, and molecular aspects. Critical Care Medicine. 2005;33:1624–1633
  25. Weekers F, Giulietti AP, Michalaki M, et al. Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. Endocrinology. 2003;144:5329–5338
  26. Hansen TK, Thiel S, Wouters PJ, et al. Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. The Journal of Clinical Endocrinology and Metabolism. 2003;88:1082–1088
  27. Joosten K, Verbruggen SC, Verhoeven JJ. Glycaemic control in paediatric critical care. Lancet. 2009;373:1423–1424
  28. Beardsall K, Vanhaesebrouck S, Ogilvy-Stuart AL, et al. Early insulin therapy in very-low-birth-weight infants. The New England Journal of Medicine. 2008;359:1873–1884
  29. Zylberberg R, Pepper M. Continuous insulin infusion: promoting growth in low birth weight infants. Neonatal Network. 2001;20:17–24
  30. Zuurbier CJ, Bos AP, van Wezel HB. Glycaemic control in paediatric critical care. Lancet. 2009;373:1423;author reply 1424
  31. Preissig C, Rigby M. Glycaemic control in paediatric critical care. Lancet. 2009;373:1423;author reply 1424
  32. Van den Berghe G. How does blood glucose control with insulin save lives in intensive care?. The Journal of Clinical Investigation. 2004;114:1187–1195
  33. Ellger B, Debaveye Y, Vanhorebeek I, et al. Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin. Diabetes. 2006;55:1096–1105
  34. Vanhorebeek I, Ellger B, De Vos R, et al. Tissue-specific glucose toxicity induces mitochondrial damage in a burn injury model of critical illness. Critical Care Medicine. 2009;37:1355–1364
  35. Preissig CM, Hansen I, Roerig PL, Rigby MR. A protocolized approach to identify and manage hyperglycemia in a pediatric critical care unit. Critical Care Medicine. 2008;9:581–588
  36. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. The New England Journal of Medicine. 2001;345:1359–1367
  37. NICE-SUGAR Study Investigators , Finfer S, Chittock DR, et al. Intensive versus conventional glucose control in critically ill patients. The New England Journal of Medicine. 2009;360:1283–1297
  38. Hoedemaekers CW, Klein Gunnewiek JM, Prinsen MA, et al. Accuracy of bedside glucose measurement from three glucometers in critically ill patients. Critical Care Medicine. 2008;36:3062–3066
  39. Kanji S, Buffie J, Hutton B, et al. Reliability of point-of-care testing for glucose measurement in critically ill adults. Critical Care Medicine. 2005;33:2778–2785
  40. Vlasselaers D, Van Herpe T, Milants I, et al. Blood glucose measurements in arterial blood of ICU patients submitted to tight glycemic control: agreement between bedside tests. Diabetes Science and Technology. 2008;2:932–938
  41. Cornblath M, Schwartz R, Aynsley-Green A, Lloyd JK. Hypoglycemia in infancy: the need for a rational definition. A Ciba Foundation Discussion Meeting. Pediatrics. 1990;85:834–837
  42. Pildes RS. Neonatal hyperglycemia. The Journal of Pediatrics. 1986;109:905–907
  43. Pildes RS, Pyati SP. Hypoglycemia and hyperglycemia in tiny infants. Clinics in Perinatology. 1986;13:351–375
  44. Malone JI, Hanna S, Saporta S, et al. Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory. Pediatric Diabetes. 2008;9:531–539
  45. Vriesendorp TM, van Santen S, DeVries JH, et al. Predisposing factors for hypoglycemia in the intensive care unit. Critical Care Medicine. 2006;34:96–101
  46. Cornblath M, Hawdon JM, Williams AF, et al. Controversies regarding definition of neonatal hypoglycemia: suggested operational thresholds. Pediatrics. 2000;105:1141–1145
  47. Lucas A, Morley R, Cole TJ. Adverse neurodevelopmental outcome of moderate neonatal hypoglycaemia. BMJ. 1988;297:1304–1308
  48. Tam EW, Widjaja E, Blaser SI, et al. Occipital lobe injury and cortical visual outcomes after neonatal hypoglycemia. Pediatrics. 2008;122:507–512
  49. Allen HF, Rake A, Roy M, et al. Prospective detection of hyperglycemia in critically ill children using continuous glucose monitoring. Pediatric Critical Care Medicine. 2008;9:153–158
  50. Vogelzang M, Zijlstra F, Nijsten MW. Design and implementation of GRIP: a computerized glucose control system at a surgical intensive care unit. BMC Medical Informatics and Decision making. 2005;5:38
  51. Vlasselaers D, Schaupp L, van den Heuvel I, et al. Monitoring blood glucose with microdialysis of interstitial fluid in critically ill children. Clinical Chemistry. 2007;53:536–537

PII: S1521-6896(09)00046-9

doi: 10.1016/j.bpa.2009.08.002

Best Practice & Research Clinical Anaesthesiology
Volume 23, Issue 4 , Pages 441-448 , December 2009

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