Best Practice & Research Clinical Anaesthesiology
Volume 23, Issue 2 , Pages 213-224 , June 2009

Pharmacokinetic aspects of fluid therapy

  • Christer H. Svensen (MD, PhD, Associate Professor)

      Affiliations

    • Karolinska Institutet, Department of Clinical Science and Education, Section of Anesthesiology and Intensive Care, Södersjukhuset, 118 83 Stockholm, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46 8 616 2226; Fax: +46 8 616 2202.
    • ,
  • Peter M. Rodhe, MSc (Research Fellow)

      Affiliations

    • Karolinska Institutet, Department of Clinical Science and Education, Section of Anesthesiology and Intensive Care, Södersjukhuset, 118 83 Stockholm, Sweden
    • ,
  • Donald S. Prough (MD, Professor)

      Affiliations

    • University of Texas Medical Branch at Galveston, Department of Anesthesiology, John Sealy Hospital, OJS2-A, 301 University Boulevard, Galveston, TX 77555-0591, USA

References 

  1. Shires GT, Williams J, Brown F. Acute changes in extracellular fluid associated with major surgical procedures. Annals of Surgery. 1961;154:803–810
  2. Shires GT, Coln D, Carrico J, Lightfoot S. Fluid therapy in hemorrhagic shock. Archives of Surgery. 1964;88:688–693
  3. Brandstrup B, Tønnesen H, Beier-Holgersen R, et al. Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens. Annals of Surgery. 2003;238:641–648
  4. Ståhle L, Nilsson A, Hahn RG. Modelling the volume of expandable body fluid spaces during i.v. fluid therapy. British Journal of Anaesthesia. 1997;78:138–143
  5. Svensen C, Hahn RG. Volume kinetics of Ringer solution, dextran 70, and hypertonic saline in male volunteers. Anesthesiology. 1997;87:204–212
  6. Hahn RG, Svensen C. Plasma dilution and the rate of infusion of Ringer's solution. British Journal of Anaesthesia. 1997;79:64–67
  7. Stanski DR. The pharmacokinetics of intravenous fluids. Anesthesiology. 1997;87:200–201
  8. Guarracino F, Lapolla F, Cariello C, et al. Target controlled infusion: TCI. Minerva Anestesiologica. 2005;71:335–337
  9. van den Nieuwenhuyzen MC, Engbers FH, Vuyk J, Burm AG. Target-controlled infusion systems: role in anaesthesia and analgesia. Clinical Pharmacokinetics. 2000;38:181–190
  10. Minto CF, Schnider TW, Gregg KM, et al. Using the time of maximum effect site concentration to combine pharmacokinetics and pharmacodynamics. Anesthesiology. 2003;99:324–333
  11. Schnider TW, Gentilini A, Wymann R. Feedback controlled anesthesia: can the computer replace the anesthesiologist?. Acta Anaesthesiologica Belgica. 2001;52:201–204
  12. Gentilini A, Frei CW, Glattfelder AH, et al. Identification and targeting policies for computer-controlled infusion pumps. Critical Reviews in Biomedical Engineering. 2000;28:179–185
  13. Tonnesen AS. Crystalloids and colloids. In:  Miller RD editors. Anesthesia. 4th edn.. New York, Edinburgh, London, Madrid, Melbounre, Milan, Tokyo: Churchill Livingstone; 1994;p. 1595–1617
  14. Prough DS, Mathru M. Acid-base, fluids, and electrolytes. In:  Barash PG,  Cullen BF,  Stoelting RK editor. Clinical anesthesia. Philadelphia: Lippincott-Raven; 1997;p. 157–187
  15. Cervera AL, Moss G. Progressive hypovolemia leading to shock after continuous hemorrhage and 3:1 crystalloid replacement. American Journal of Surgery. 1975;129:670–674
  16. Riddez L, Hahn RG, Brismar B, et al. Central and regional hemodynamics during acute hypovolemia and volume substitution in volunteers. Critical Care Medicine. 1997;25:635–640
  17. Brandstrup B, Svensen C, Engquist A. Hemorrhage and surgery cause a contraction of the extracellular space needing replacement – evidence and implications. Surgery. 2006;139:419–432
  18. Moore FD, Dagher FJ, Boyden CM, et al. Hemorrhage in normal man: I. Distribution and dispersal of saline infusions following acute blood loss. Annals of Surgery. 1966;163:485–504
  19. Hahn RG, Prough DS, Svensen C. Perioperative fluid management. New York: Informa Healthcare USA, Inc.; 2007;
  20. Nadler SB, Hidalgo JU, Bloch T. Prediction of blood volume in normal human adults. Surgery. 1962;51:224–232
  21. Drobin D & Hahn RG. Time course of increased haemodilution in hypotension induced by extradural anaesthesia. British Journal of Anaesthesia 1996; 77: 223–226.
  22. Hahn RG. Blood volume at the onset of hypotension in TURP performed during epidural anaesthesia. European Journal of Anaesthesiology. 1993;10:219–225
  23. Chaplin H, Mollison PL, Vetter H. The body/venous hematocrit ratio: its constancy over a wide hematocrit range. The Journal of Clinical Investigation. 1953;32:1309–1316
  24. Ebert RV, Stead EA, Gibson JG. Response of normal subjects to acute blood loss. Archives of Internal Medicine. 1941;68:578–590
  25. Motulsky HJ, Ransnas LA. Fitting curves to data using nonlinear regression: a practical and nonmathematical review. The FASEB Journal. 1987;1:365–374
  26. Prough DS, Michenfelder JD. Cerebral blood flow and metabolism: implications for clinical monitoring. In: Critical care medicine: state of the art. Fullerton, CA: Society of Critical Care Medicine; 1989;p. 43–70
  27. Boxenbaum HG, Riegelman S, Elashoff RM. Statistical estimations in pharmacokinetics. Journal of Pharmacokinetics and Biopharmaceutics. 1974;2:123–148
  28. Drobin D. A single-model solution for volume kinetic analysis of isotonic fluid infusions. Acta Anaesthesiologica Scandinavica. 2006;50:1074–1080
  29. Svensen C, Brauer KI, Hahn R, et al. Elimination rate constant describing clearance of 0.9% saline from plasma is independent of infused volume in sheep. Anesthesiology. 2004;101:666–674
  30. Hahn RG. Increased haemodilution in hypotension induced by epidural anaesthesia. Acta Anaesthesiologica Scandinavica 1993; 37: 357–360.
  31. Hahn RG. Origin of intravascular fluid recruited by vasodilatation during epidural anaesthesia. European Surgical Research. 1996;28:70–74
  32. Holte K, Foss N, Svensen C, et al. Epidural anesthesia and intravascular volume. Anesthesiology. 2004;100:281–286
  33. Hahn RG, Resby M. Volume kinetics of Ringer's solution and dextran 3% during induction of spinal anaesthesia for caesarean section. Canadian Journal of Anaesthesia. 1998;45:443–451
  34. Li Y, Zhu S, Hahn RG. The kinetics of Ringeŕs solution in young and elderly patients during induction of general anesthesia with propofol and epidural anesthesia with ropivacaine. Acta Anaesthesiologica Scandinavica. 2007;51:880–887
  35. Ewaldsson C-A, Hahn RG. Volume kinetics if Ringer's solution during induction of spinal anaesthesia. British Journal of Anaesthesia. 2001;87:406–414
  36. Ewaldsson C-A, Hahn RG. Bolus injection of Ringeŕs solution and dextran 1kDa during induction of spinal anesthesia. Acta Anaesthesiologica Scandinavica. 2005;49:152–159
  37. Brauer KI, Svensen C, Hahn RG, et al. Volume kinetic analysis of the distribution of 0.9% saline in conscious versus isoflurane-anesthetized sheep. Anesthesiology. 2002;96:442–449
  38. Conolly C, Kramer GC, Hahn RG, et al. Isoflurane but not mechanical ventilation promotes third-space fluid losses during crystalloid volume loading. Anesthesiology. 2003;98:670–681
  39. Norberg Å, Brauer K, Prough D, et al. Volume turnover kinetics of fluid shifts in sheep after hemorrhage, fluid infusion and the combination of hemorrhage and fluid infusion. Anesthesiology. 2005;102:985–994
  40. Ewaldsson C-A, Hahn RG. Kinetics and extravascular retention of acetated Ringeŕs solution during isoflurane or propofol anesthesia for thyroid surgery. Anesthesiology. 2005;103:460–469
  41. Hahn R, Brauer LP, Rodhe P, et al. Isoflurane inhibits transcapillary compensatory volume expansion. Anesthesia and Analgesia. 2006;103:350–358
  42. Svensen C, Clifton B, Brauer K, et al. Sepsis produced by Pseudomonas bacteremia does not alter volume expansion after 0.9% saline infusion in sheep. Anesthesia and Analgesia. 2005;101:832–845
  43. Dubniks M, Persson J, Grande P-O. Effect of blood pressure on plasma volume loss in the rat under increased permeability. Intensive Care Medicine. 2007;33:2192–2198
  44. Vane LA, Prough DS, Williams CA, Kramer GC. Effects of catecholamines on volume expansion and hemodynamic responses of crystalloid infusion. Orlando, FL: American Society of Anesthesiologists; 2002;A678
  45. Svensen C, Ponzer S, Hahn RG. Volume kinetics of Ringer solution after surgery for hip fracture. Canadian Journal of Anaesthesia. 1999;46:133–141
  46. Strandberg P, Hahn RG. Volume kinetics of glucose 2.5% solution and insulin resistance after abdominal hysterectomy. British Journal of Anaesthesia. 2005;94:30–38
  47. Sjöstrand F, Hahn RG. Validation of volume kinetic analysis of glucose 2.5% solution given by intravenous infusion. British Journal of Anaesthesia. 2003;90:600–607
  48. Drobin D, Hahn RG. Volume kinetics of Ringer's solution in hypovolemic volunteers. Anesthesiology. 1999;90:81–91
  49. Olsson J, Svensen C, Hahn RG. The volume kinetics of acetated Ringer's solution during laparoscopic cholecystectomy. Anesthesia and Analgesia. 2004;99:1854–1860

PII: S1521-6896(08)00100-6

doi: 10.1016/j.bpa.2008.11.003

Best Practice & Research Clinical Anaesthesiology
Volume 23, Issue 2 , Pages 213-224 , June 2009

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