Best Practice & Research Clinical Anaesthesiology
Volume 22, Issue 3 , Pages 437-449 , September 2008

Ventilator-associated pneumonia: Problems with diagnosis and therapy

References 

  1. Johanson WG, Pierce AK, Sanford JP, et al. Nosocomial respiratory infections with gram-negative bacilli: the significance of colonization of the respiratory tract. Annals of Internal Medicine. 1972;77:701–706
  2. Sottile FD, Marrie TJ, Prough DS, et al. Nosomical pulmonary infection: possible aetiologic significance of bacterial adhesion to the endotracheal tube. Critical Care Medicine. 1986;14:265–270
  3. Feldman C, Kassel M, Cantrell J, et al. The presence and sequence of endotracheal tube colonization in patients undergoing mechanical ventilation. European Respiratory Journal. 1999;13:546–551
  4. Bahrani-Mougeot FK, Paster BJ, Coleman S, et al. Molecular analysis of oral and respiratory bacterial species associated with ventilator-associated pneumonia. Journal of Clinical Microbiology. 2007;45:1588–1593
  5. Flanagan J, Li W, Lynch SV, et al. Changes in bacterial diversity in intubated patients colonized with P. aeruginosa. Journal of Clinical Microbiology. 2007;45:1954–1962
  6. Fabregas N, Ewig S, Torres A, et al. Clinical diagnosis of ventilator associated pneumonia revisited: comparative validation using immediate post-mortem lung biopsies. Thorax. 1999;54:867–873
  7. Flanders SA, Dudas V, Kerr K, et al. Nosocomial pneumonia: state of the science. American Journal of Infection Control. 2006;34:84–93
  8. Guidelines for the management of adults with hospital-acquired, ventilator-associated and healthcare-associated pneumonia. American Journal of Respiratory and Critical Care Medicine. 2005;171:388–416
  9. Jackson WL, Shorr AF. Update in ventilator-associated pneumonia. Current Opinion in Anaesthesiology. 2006;19:117–121
  10. Ibrahim EH, Ward S, Sherman G, et al. A comparative analysis of patients with early-onset vs late-onset nosocomial pneumonia in the ICU setting. Chest. 2000;117:1434–1442
  11. Cavalcanti M, Ferrer M, Ferrer R, et al. Risk and prognostic factors of ventilator-associated pneumonia in trauma patients. Critical Care Medicine. 2006;34:1067
  12. Stéphan F, Mabrouk N, Decailliot F, et al. Ventilator-associated pneumonia leading to acute lung injury after trauma: importance of Haemophilus influenzae. Anesthesiology. 2006;104:235–241
  13. Jacobs R, Wiener-Kronish JP. Endotracheal tubes; the conduit for oral and nasal microbial communities to the lungs. Anesthesiology. 2006;104:224–225
  14. Mayhall CG. Ventilator-associated pneumonia or not? Contemporary diagnosis. Emerging Infectious Diseases. 2001;7:200–204
  15. Jourdain B, Novara A, Joly-Guillou ML, et al. Role of quantitative cultures of endotracheal aspirates in the diagnosis of nosocomial pneumonia. American Journal of Respiratory and Critical Care Medicine. 1995;152:241–246
  16. Chastre J, Viau F, Brun P, et al. Prospective evaluation of the protected specimen brush for the diagnosis of pulmonary infections in ventilated patients. American Review of Respiratory Disease. 1984;130:924–929
  17. Chastre J, Fagon JY, Bornet-Lecso M, et al. Evaluation of bronchoscopic techniques for the diagnosis of nosocomial pneumonia. American Journal of Respiratory and Critical Care Medicine. 1995;152:231–240
  18. Fagon JY, Chastre J. Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia: a randomized trial. Annals of Internal Medicine. 2000;132:621–630
  19. Kollef MH, Kollef KE. Antibiotic utilization and outcomes for patients with clinically suspected ventilator-associated pneumonia and negative quantitative BAL culture results. Chest. 2005;128:2706–2713
  20. Shorr AF, Sherner JH, Jackson WL, et al. Invasive approaches to the diagnosis of ventilator-associated pneumonia; a meta analysis. Critical Care Medicine. 2005;33:46–53
  21. Croce MA, Swanson JM, Magnotti LJ, et al. The futility of the clinical pulmonary infection score in trauma patients. The Journal of Trauma. 2006;60:523–528
  22. Azoulay E, Mokart D, Rabbat A, et al. Diagnostic bronchoscopy in hematology and oncology patients with acute respiratory failure: prospective multicenter data. Critical Care Medicine. 2008;36:100–107
  23. Bregeon F, Papazian L, Thomas , et al. Diagnostic accuracy of protected catheter sampling in ventilator-associated bacterial pneumonia. European Respiratory Journal. 2000;16:969–975
  24. Baram D. Stable patients receiving prolonged mechanical ventilation have a high alveolar burden of bacteria. Chest. 2005;127:1353–1357
  25. Gibot S, Cravoisy A, Levy B, et al. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. The New England Journal of Medicine. 2004;350:451–458
  26. Determann RM, Millo JL, Gibot S, et al. Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia. Intensive Care Medicine. 2005;31:1495–1500
  27. Choi G, Schultz MJ, van Till JW, et al. Disturbed alveolar fibrin turnover during pneumonia is restricted to the site of infection. European Respiratory Journal. 2004;24:786–789
  28. Schultz MJ, Haitsma JJ, Zhang H, et al. Pulmonary coagulopathy as a new target in therapeutic studies of acute lung injury or pneumonia-a review. Critical Care Medicine. 2006;34:871–877
  29. Prabhakaran P, Ware LB, White KE, et al. Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2003;285:L20–L28
  30. Lisboa T, Seligman R, Diaz E, et al. C-reactive protein correlates with bacterial load and appropriate antibiotic therapy in suspected ventilator-associated pneumonia. Critical Care Medicine. 2008;36:166–171
  31. Chastre J, Wolff M, Fagon JY, et al. Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial. JAMA. 2003;290:2588–2598
  32. Aarts M-AW, Hancock JN, Heyland D, et al. Empiric antibiotic therapy for suspected ventilator-associated pneumonia: a systematic review and meta-analysis of randomized trials. Critical Care Medicine. 2008;36:108–117
  33. Singh N, Rogers P, Atwood CW, et al. Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit: a proposed solution for indiscriminate antibiotic prescription. American Journal of Respiratory and Critical Care Medicine. 2000;162:505–511
  34. Combes A, Luyt C-E, Fagon J-Y, et al. Early predictors for infection recurrence and death in patients with ventilator-associated pneumonia. Critical Care Medicine. 2007;35:146–154
  35. Carson SS, Kress JP, Rodgers JE, et al. A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients. Critical Care Medicine. 2006 May;34(5):1326–1332
  36. Girou E, Schortgen F, Delclaux C, et al. Association of noninvasive ventilation with nosocomial infections and survival in critically ill patients. JAMA. 2000;284:2361–2367
  37. Doebbeling BN, Stanley GL, Sheetz CT, et al. Comparative efficacy of alternative hand-washing agents in reducing nosocomial infections in intensive care units. The New England Journal of Medicine. 1992;327:88–93
  38. Depuydt PO, Blot SI, Benoit DD, et al. Antimicrobial resistance in nosocomial bloodstream infection associated with pneumonia and the value of systematic surveillance cultures in an adult intensive care unit. Critical Care Medicine. 2006;34:653–659
  39. Delclaux C, Roupie E, Blot F, et al. Lower respiratory tract colonization and infection during severe acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine. 1997;156:1092–1098
  40. Hayon J, Figliolini C, Combes A, et al. Role of serial routine microbiologic culture results in the initial management of ventilator-associated pneumonia. American Journal of Respiratory and Critical Care Medicine. 2002;165:41–46
  41. Bouza E, Pérez A, Muñoz P, et al. Ventilator-associated pneumonia after heart surgery: a prospective analysis and the value of surveillance. Critical Care Medicine. 2003;31:1964–1970
  42. Bouza E, Muñoz P, Burillo A, et al. The challenge of anticipating catheter tip colonization in major heart surgery patients in the intensive care unit: Are surface cultures useful. Critical Care Medicine. 2005;33:1953–1960
  43. Metheny NA, Clouse RE, Chang YH, et al. Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients: frequency, outcomes and risk factors. Critical Care Medicine. 2006;34:1007–1015
  44. Marik PE, Zaloga GP. Gastric versus post-pyloric feeding: a systematic review. Crit Care [London]. 2003;7:R46–R51
  45. Young PJ, Pakeerathan S, Blunt MC, et al. A low-volume, low pressure tracheal tube cuff reduces pulmonary aspiration. Critical Care Medicine. 2006;34:632–639
  46. Terpenning M. Geriatric oral health and pneumonia risk. Clinical Infectious Diseases. 2005;40:1807–1810
  47. Sequin P, Tanguy M, Laviolle B, et al. Effect of oropharyngeal decontamination by povidone-iodine on ventilator-associated pneumonia in patients with head trauma. Critical Care Medicine. 2006 May;34(5):1514–1519
  48. Mori H, Hirasawa H, Oda S, et al. Oral care reduces incidence of ventilator-associated pneumonia in ICU populations. Intensive Care Medicine. 2006;32:230–236
  49. Koeman M, van der Ven AJAM, Hak E, et al. Oral decontamination with chlorhexidine reduces the incidence of ventilator-associated pneumonia. American Journal of Respiratory and Critical Care Medicine. 2006;173:1348–1355
  50. Segers P, Speekenbrink RGH, Ubbink DT, et al. Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate-a randomized controlled trial. JAMA. 2006;296:2460–2466
  51. Chlebicki MP, Safdar N. Topical chlorhexidine for prevention of ventilator-associated pneujmonia: a meta-analysis. Critical Care Medicine. 2007;35:595–602

PII: S1521-6896(08)00034-7

doi: 10.1016/j.bpa.2008.05.002

Best Practice & Research Clinical Anaesthesiology
Volume 22, Issue 3 , Pages 437-449 , September 2008