Best Practice & Research Clinical Anaesthesiology
Volume 22, Issue 2 , Pages 253-263, June 2008

Physiology of the vasopressin receptors

  • Marc O. Maybauer, MD, PhD (Assistant Professor in Anesthesiology)
    • ,
  • Dirk M. Maybauer, MD, PhD (Assistant Professor in Anesthesiology)
    • ,
  • Perenlei Enkhbaatar, MD, PhD (Associate Professor of Anesthesiology Associate Director in The Investigative Intensive Care Unit)
    • ,
  • Daniel L. Traber, PhD, FCCM (Charles Robert Allen Professor of Anesthesiology Director in The Investigative Intensive Care Unit Professor of Neuroscience and Cell Biology)

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1 409 772 6405; Fax: +1 409 772 6409.

The University of Texas Medical Branch and Shriners Burns Hospital, Department of Anesthesiology, Investigational Intensive Care Unit, 301 University Boulevard, Galveston, TX 77555-0833, USA

This review article summarizes the structure, signalling pathways, and tissue distribution of the vasopressin receptors, V1 vascular, V2 renal, V3 pituitary, and oxytocin receptors, as well as the P2 class of purinoceptors. The physiological effects of vasopressin on its receptors are described. The future direction with regard to the role of the V1a receptor in circulatory shock states is discussed; further studies with V1a receptor agonists are warranted to further develop treatment strategies to reduce mortality in life threatening diseases like septic shock.

Key words: vasopressin (VP), sepsis, V1 receptor agonist, vasopressin, oxytocin (ot), amino acid sequences, hypovolemia, arginine-vasopressin (AVP)

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PII: S1521-6896(08)00027-X

doi:10.1016/j.bpa.2008.03.003

Best Practice & Research Clinical Anaesthesiology
Volume 22, Issue 2 , Pages 253-263, June 2008

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