Best Practice & Research Clinical Anaesthesiology
Volume 22, Issue 2 , Pages 275-286, June 2008

Arginine vasopressin in the treatment of vasodilatory septic shock☆

  • Cheryl L. Holmes, MD, FRCPC (Clinical Instructor)

      Affiliations

    • Tel.: +1 250 212 9450; Fax: +1 250 764 9083.
  • Keith R. Walley, MD, FRCPC (Professor of Medicine)

      Affiliations

    • Corresponding Author InformationCorresponding author. Keith R. Walley, MD, UBC McDonald Research Laboratories, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6. Tel.: +604 806 8136; Fax: +604 806 8351.

University of British Columbia, Division of Critical Care, Department of Medicine, Kelowna General Hospital, BC, Canada

University of British Columbia, Division of Critical Care, Department of Medicine, St. Paul's Hospital, Vancouver, BC, Canada

Vasodilatory septic shock is characterized by profound vasodilation of the peripheral circulation, relative refractoriness to catecholamines and a relative deficiency of the posterior pituitary hormone, vasopressin. Arginine vasopressin is effective in restoring vascular tone in vasodilatory septic shock and may be associated with decreased mortality in less severe septic shock as well as improved mortality and decreased renal failure in septic shock patients at risk for renal failure.

Key words: acute renal failure, adrenergic agents, antidiuretic hormone, arginine Vasopressin, hypotension, muscle, smooth, vascular/physiology, norepinephrine, nitric oxide, potassium channels, shock, septic, vasoconstriction, vasodilation, vasopressin

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

☆ Support: Heart & Stroke Foundation of B.C. and Yukon. Keith R. Walley is a B.C. Lung Association/St. Paul's Hospital Foundation Scientist.

PII: S1521-6896(08)00026-8

doi:10.1016/j.bpa.2008.03.002

Best Practice & Research Clinical Anaesthesiology
Volume 22, Issue 2 , Pages 275-286, June 2008

Article Tools

* Image Usage & Resolution