Best Practice & Research Clinical Anaesthesiology
Volume 21, Issue 2 , Pages 163-171 , June 2007

Allogeneic red blood cell transfusion: Physiology of oxygen transport

  • Donat R. Spahn, MD, FRCA (Professor and Chairman)

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +41 44 255 26 95; Fax: +41 44 255 44 09.

References 

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  5. Jamnicki M, Kocian R, van der Linden P, et al. Acute normovolemic hemodilution: physiology, limitations, and clinical use. Journal of Cardiothoracic and Vascular Anesthesia. 2003;17:747–754
  6. Habler OP, Kleen MS, Hutter JW, et al. Effects of hyperoxic ventilation on hemodilution-induced changes in anesthetized dogs. Transfusion. 1998;38:135–144
  7. Habler OP, Kleen MS, Hutter JW, et al. Hemodilution and intravenous perflubron emulsion as an alternative to blood transfusion: effects on tissue oxygenation during profound hemodilution in anesthetized dogs. Transfusion. 1998;38:145–155
  8. Pape A, Meier J, Kertscho H, et al. Hyperoxic ventilation increases the tolerance of acute normovolemic anemia in anesthetized pigs. Critical Care Medicine. 2006;34:1475–1482
  9. Kleen M, Messmer K. Toxicity of high PaO2. Minerva Anestesiologica. 1999;65:393–396
  10. Meier J, Kemming GI, Kisch-Wedel H, et al. Hyperoxic ventilation reduces 6-hour mortality at the critical hemoglobin concentration. Anesthesiology. 2004;100:70–76
  11. Suttner S, Piper SN, Kumle B, et al. The influence of allogeneic red blood cell transfusion compared with 100% oxygen ventilation on systemic oxygen transport and skeletal muscle oxygen tension after cardiac surgery. Anesthesia and Analgesia. 2004;99:2–11
  12. Weiskopf RB, Feiner J, Hopf HW, et al. Oxygen reverses deficits of cognitive function and memory and increased heart rate induced by acute severe isovolemic anemia. Anesthesiology. 2002;96:871–877
  13. Morisaki H, Sibbald WJ. Tissue oxygen delivery and the microcirculation. Critical Care Clinics. 2004;20:213–223
  14. Habler O, Kleen M, Podtschaske A, et al. The effect of acute normovolemic hemodilution (ANH) on myocardial contractility in anesthetized dogs. Anesthesia and Analgesia. 1996;83:451–458
  15. Spahn DR, Leone BJ, Reves JG, et al. Cardiovascular and coronary physiology of acute isovolemic hemodilution: a review of nonoxygen-carrying and oxygen-carrying solutions. Anesthesia and Analgesia. 1994;78:1000–1021
  16. Weiskopf RB, Feiner J, Hopf H, et al. Heart rate increases linearly in response to acute isovolemic anemia. Transfusion. 2003;43:235–240
  17. Spahn DR, Seifert B, Pasch T, et al. Effects of chronic beta-blockade on compensatory mechanisms during acute isovolaemic haemodilution in patients with coronary artery disease. British Journal of Anaesthesia. 1997;78:381–385
  18. Eagle KA, Berger PB, Calkins H, et al. ACC/AHA guideline update for perioperative cardiovascular evaluation for noncardiac surgery–executive summary a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1996 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). Circulation. 2002;105:1257–1267
  19. Spahn DR, Schmid ER, Seifert B, et al. Hemodilution tolerance in patients with coronary artery disease who are receiving chronic beta-adrenergic blocker therapy. Anesthesia and Analgesia. 1996;82:687–694
  20. Licker M, Ellenberger C, Sierra J, et al. Cardiovascular response to acute normovolemic hemodilution in patients with coronary artery diseases: Assessment with transesophageal echocardiography. Critical Care Medicine. 2005;33:591–597
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  22. Licker M, Ellenberger C, Murith N, et al. Cardiovascular response to acute normovolaemic haemodilution in patients with severe aortic stenosis: assessment with transoesophageal echocardiography. Anaesthesia. 2004;59:1170–1177
  23. Spahn DR, Seifert B, Pasch T, et al. Haemodilution tolerance in patients with mitral regurgitation. Anaesthesia. 1998;53:20–24
  24. Hebert PC, McDonald BJ, Tinmouth A. Clinical consequences of anemia and red cell transfusion in the critically ill. Critical Care Clinics. 2004;20:225–235
  25. Cabrales P, Martini J, Intaglietta M, et al. Blood viscosity maintains microvascular conditions during normovolemic anemia independent of blood oxygen-carrying capacity. American Journal of Physiology. Heart and Circulatory Physiology. 2006;291:H581–H590

PII: S1521-6896(07)00002-X

doi: 10.1016/j.bpa.2007.01.001

Best Practice & Research Clinical Anaesthesiology
Volume 21, Issue 2 , Pages 163-171 , June 2007

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