Best Practice & Research Clinical Anaesthesiology
Volume 21, Issue 1 , Pages 51-63 , March 2007

Do we need preemptive analgesia for the treatment of postoperative pain?

  • Sina Grape, MD (Resident in Anaesthesiology)

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +41 22 382 74 41; Fax: +41 22 382 75 11.
    • ,
  • Martin R. Tramèr, MD, DPhil (Professor of Anaesthesiology)

References 

  1. Katz J. George Washington Crile, anoci-association and pre-emptive analgesia. Pain. 1993;53:243–245
  2. Woolf CJ. Evidence for a central component of post-injury pain hypersensitivity. Nature. 1983;306:686–688
  3. Costigan M, Woolf CJ. Pain: molecular mechanisms. Journal of Pain. 2000;1(3 supplement):35–44
  4. Brennan TJ. Frontiers in translational research: the etiology of incisional and postoperative pain. Anesthesiology. 2002;97:535–537
  5. Hunt JL, Winkelstein BA, Rutkowski MD, et al. Repeated injury to the lumbar nerve roots produces enhanced mechanical allodynia and persistent spinal neuroinflammation. Spine. 2001;26:2073–2079
  6. Melzack R, Lariviere WR. The role of corticotropin-releasing factor in pain and analgesia. Pain. 2000;84:1–12
  7. Randic M, Jiang MC, Rusin KI, et al. Interactions between excitatory amino acids and tachykinins and long-term changes of synaptic responses in the rat spinal dorsal horn. Regulatory Peptides. 1993;46:418–420
  8. Ahmadi S, Lippross S, Neuhuber WL, et al. PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons. Nature Neuroscience. 2002;5:34–40
  9. Kress M, Koltzenburg M, Reeh PW, et al. Responsiveness and functional attributes of electrically localized terminals of cutaneous C-fibers in vivo and in vitro. Journal of Neurophysiology. 1992;68:581–595
  10. Melzack R, Coderre TJ, Katz J, et al. Central neuroplasticity and pathological pain. Annals of the New York Academy of Sciences. 2001;933:157–174
  11. McMahon SB, Wall PD. Receptive fields of rat lamina 1 projection cells move to incorporate a nearby region of injury. Pain. 1984;19:235–247
  12. Woolf CJ, King AE. Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord. Journal of Neuroscience. 1990;10:2717–2726
  13. Cameron AA, Cliffer KD, Dougherty PM, et al. Changes in lectin, GAP-43 and neuropeptide staining in the rat superficial dorsal horn following experimental peripheral neuropathy. Neuroscience Letters. 1991;131:249–252
  14. Coderre TJ, Melzack R. Excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury. Journal of Neuroscience. 1992;12:3665–3670
  15. Kissin I. Preemptive analgesia: terminology and clinical relevance. Anesthesia and Analgesia. 1994;79:809–810
  16. Perkins FM, Kehlet H. Chronic pain as an outcome of surgery. A review of predictive factors. Anesthesiology. 2000;93:1123–1133
  17. Macrae WA. Chronic pain after surgery. British Journal of anaesthesia. 2001;87(1):88–98
  18. Scholz J, Woolf CJ. Can we conquer pain?. Nature Neuroscience. 2002;5(supplement):1062–1067
  19. Alhaider AA, Lei SZ, Wilcox GL. Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA. Journal of Neuroscience. 1991;11:1881–1888
  20. Woolf CJ, Thompson SW. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain. 1991;44:293–299
  21. Fisher K, Coderre TJ, Hagen NA. Targeting the N-methyl-D-aspartate receptor for chronic pain management. Preclinical animal studies, recent clinical experience and future research directions. Journal of Pain and Symptom Management. 2000;20:358–373
  22. Davar G, Hama A, Deykin A, et al. MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy. Brain Research. 1991;12(553):327–330
  23. Mao J, Price DD, Hayes RL, et al. Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy. Brain Research. 1992;598:271–278
  24. Baumann TK, Simone DA, Shain CN, et al. Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia. Journal of Neurophysiology. 1991;66:212–227
  25. LaMotte RH, Shain CN, Simone DA, et al. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. Journal of Neurophysiology. 1991;66:190–211
  26. Woolf CJ, Wall PD. Morphine-sensitive and morphine-insensitive actions of C-fibre input on the rat spinal cord. Neuroscience Letters. 1986;28:221–225
  27. Dickenson AH, Sullivan AF. Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: differential response to an intrathecal opiate administered pre or post formalin. Pain. 1987;30:349–360
  28. Seltzer Z, Beilin BZ, Ginzburg R, et al. The role of injury discharge in the induction of neuropathic pain behavior in rats. Pain. 1991;46:327–336
  29. Dougherty PM, Garrison CJ, Carlton SM. Differential influence of local anesthetic upon two models of experimentally induced peripheral mononeuropathy in the rat. Brain Research. 1992;570:109–115
  30. Coderre TJ, Vaccarino AL, Melzack R. Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection. Brain Research. 1990;535:155–158
  31. Vaccarino AL, Melzack R. Temporal processes of formalin pain: differential role of the cingulum bundle, fornix pathway and medial bulboreticular formation. Pain. 1992;49:257–271
  32. Haley JE, Sullivan AF, Dickenson AH. Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat. Brain Research. 1990;518:218–226
  33. Yamamoto T, Yaksh TL. Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: antinociception in the absence of motor dysfunction. Life Sciences. 1991;49:1955–1963
  34. McQuay HJ. Pre-emptive analgesia: a systematic review of clinical studies. Annals of Medicine. 1995;27:249–256
  35. Kelly DJ, Ahmad M, Brull SJ. Preemptive analgesia II: recent advances and current trends. Canadian Journal of Anaesthesia. 2001;48:1091–1101
  36. Møiniche S, Kehlet H, Dahl JB. A qualitative and quantitative systematic review of preemptive analgesia for postoperative pain relief: the role of timing of analgesia. Anesthesiology. 2002;96:725–741
  37. McCartney CJ, Sinha A, Katz J. A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia. Anesthesia and Analgesia. 2004;98:1385–1400
  38. Ong CKS, Philipp L, Robin AS, et al. The efficacy of preemptive analgesia for acute postoperative pain management: a meta-analysis. Anesthesia and Analgesia. 2005;100:757–773
  39. Bong CL, Samuel M, Ng JM, et al. Effects of preemptive epidural analgesia on post-thoracotomy pain. Journal of Cardiothoracic and Vascular Anesthesia. 2005;19:786–793
  40. Katz J, Cohen L, Schmid R, et al. Postoperative morphine use and hyperalgesia are reduced by preoperative but not intraoperative epidural analgesia: implications for preemptive analgesia and the prevention of central sensitization. Anesthesiology. 2003;98:1449–1460
  41. Katz J, Schmid R, Snijdelaar DG, et al. Pre-emptive analgesia using intravenous fentanyl plus low-dose ketamine for radical prostatectomy under general anesthesia does not produce short-term or long-term reductions in pain or analgesic use. Pain. 2004;110:707–718
  42. Lavand'homme P, De Kock M, Waterloos H. Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery. Anesthesiology. 2005;103:813–820
  43. Hogan QH. No preemptive analgesia: is that so bad?. Anesthesiology. 2002;96:526–527
  44. Kissin I. Preemptive analgesia. Why its effect is not always obvious. Anesthesiology. 1996;84:1015–1019
  45. Kissin I. Preemptive analgesia. Anesthesiology. 2000;93:1138–1143
  46. Coderre TJ, Katz J, Vaccarino AL, et al. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain. 1993;52:259–285
  47. Brennan TJ, Umali EF, Zahn PK. Comparison of pre- versus post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model of postoperative pain. Anesthesiology. 1997;87:1517–1528
  48. Pogatzki EM, Zahn PK, Brennan TJ. Effect of preemptive with intrathecal excitatory amino acid receptor antagonists on the development of pain behavior caused by plantar incision. Anesthesiology. 2000;93:489–496
  49. Nolan A, Reid J. Comparison of the postoperative analgesic and sedative effects of carprofen and papaveretum in the dog. The Veterinary Record. 1993;133:240–242
  50. Hogan Q. Animal pain models. Regional Anesthesia and Pain Medicine. 2002;27(4):385–401
  51. Moller IW, Rem J, Brandt MR, et al. Effect of posttraumatic epidural analgesia on the cortisol and hyperglycemic response to surgery. Acta Anaesthesiologica Scandinavica. 1982;26:56–58
  52. Dierking GW, Dahl JB, Kanstrup J, et al. Effect of pre- vs postoperative inguinal field block on postoperative pain after herniorrhaphy. British Journal of Anaesthesia. 1992;68:344–348
  53. Fields HL. Pain modulation: expectation, opioid analgesia and virtual pain. Progress in Brain Research. 2000;122:245–253
  54. Kalso E, Smith L, McQuay HJ, et al. No pain, no gain: clinical excellence and scientific rigour. Lessons learned from IA morphine. Pain. 2002;98:269–275

PII: S1521-6896(06)00078-4

doi: 10.1016/j.bpa.2006.11.004

Best Practice & Research Clinical Anaesthesiology
Volume 21, Issue 1 , Pages 51-63 , March 2007

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