Best Practice & Research Clinical Anaesthesiology
Volume 20, Issue 1 , Pages 11-22 , March 2006

Unconsciousness

  • Hans Flohr, MD (Professor)

      Affiliations

    • Corresponding Author InformationTel.: +49 421 218 3371; fax: +49 421 218 4932.

References 

  1. Müller GE. Zur Psychophysik der Gesichtsempfindungen. Zeitschrift für Psychologie und Physiologie der Sinnesorgane. 1896;10:1–82
  2. Du Bois-Reymond E. Über die Grenzen des Naturerkennens. Leipzig: Veit & Co; 1916;
  3. Churchland PS. Brain-wise. Studies in Neurophilosophy. Cambridge (MA): MIT Press; 2002;
  4. Armstrong D. A Materialist Theory of Mind. London: Routledge & Kegan Paul; 1968;
  5. Churchland P. Matter and Consciousness: A Contemporary Introduction to the Philosophy of Mind. Cambridge (MA): MIT Press; 1988;
  6. Rosenthal D. Thinking that one thinks. In:  Davies M,  Humphreys G editor. Consciousness. Cambridge (MA): Blackwell; 1993;p. 197–223
  7. Rosenthal D. Higher-order thoughts and the appendage theory of consciousness. Philosophy of Psychology. 1991;6:155–166
  8. Flohr H. Brain Processes and phenomenal consciousness: a new and specific hypothesis. Theory of Psychology. 1991;1:245–262
  9. Flohr H. In:  Elbert T,  Birbaumer N editor. Die physiologischen Grundlagen des Bewußtseins. Enzyklopädie der Psychologie. Biologische Grundlagen der Psychologie. vol. 6:Göttingen Bern Toronto Seattle: Hogrefe; 2002;p. 35–86
  10. Metzinger T. Being No One: The Self-Model Theory of Subjectivity. Cambridge (MA): MIT Press; 2003;
  11. Lycan WG. Consciousness and Experience. Cambridge (MA): MIT Press; 1996;
  12. Carruthers P. Language, Thought and Consciousness. Cambridge: Cambridge University Press; 1996;
  13. Hebb DO. The Organization of Behavior. New York: Wiley; 1949;
  14. von Hajek FH. The Sensory Order—An Inquiry into the Foundations of Theoretical Psychology. London: Routledge; 1952;
  15. von der Malsburg C. The correlation theory of brain function. Internal report 81/2. Göttingen: Max-Planck-Institut für Biophysikalische Chemie, Abteilung für Neurobiologie; 1981.
  16. Smart TG. Regulation of excitatory and inhibitory neurotransmitter-gated ion channels by protein phosphorylation. Current Opinion in Neurobiology. 1997;7:358–367
  17. Salter MW, Kalia LV. SRC kinases: a hub for NMDA receptor regulation. Nature Reviews Neuroscience. 2004;5:317–328
  18. Flohr H. An information processing theory of anaesthesia. Neuropsychologia. 1995;33:1169–1180
  19. Ryder S, Way WL, Trevor AJ. Comparative pharmacology of the optical isomers of ketamine in mice. European Journal of Pharmacology. 1978;49:15–23
  20. White PF, Ham J, Way WL, Trevor AJ. Pharmacology of ketamine isomers in surgical patients. Anesthesiology. 1980;52:231–239
  21. Irifune M, Shimizu T, Nomoto M, Fukuda T. Ketamine induced anesthesia involves the N-methyl-d-aspartate receptor-channel complex in mice. Brain Research. 1992;596:1–9
  22. France CP, Winger GD, Woods JH. Analgesic, anesthetic and respiratory effects of the competitive N-methyl-d-aspartate (NMDA) antagonist CGS 19755 in rhesus monkeys. Brain Research. 1990;526:335–358
  23. Kuroda Y, Strebel S, Rafferty C, Bullock R. Neuroprotective doses of N-methyl-d-aspartate receptor antagonists profoundly reduce the minimum alveolar anaesthetic concentration (MAC) for isoflurane in rats. Anesthesia and Analgesia. 1993;77:795–800
  24. McFarlane C, Warner DS, Nader A, Dexter F. Glycine receptor antagonism, effects of ACEA 1021 on the minimum alveolar concentration for halothane in the rat. Anesthesiology. 1995;82:961–968
  25. Johns RA, Moscicki JC, DiFazio CA. Nitric oxide synthase inhibitor dose- dependently and reversibly reduces the threshold for halothane anesthesia. Anesthesiology. 1992;77:779–784
  26. Motzko D, Glade U, Tober C, Flohr H. 7-Nitro indazole enhances methohexital anesthesia. Brain Research. 1998;788:353–355
  27. Flohr H, Glade U, Motzko D. The role of the NMDA synapse in general anesthesia. Toxicology Letters. 1998;100–101:23–29
  28. Flohr H. NMDA receptor-mediated computational processes and phenomenal consciousness. In:  Metzinger T editors. Neural Correlates of Consciousness. Cambridge (MA): MIT Press; 2000;p. 245–258
  29. Zuo Z, Johns RA. Halothane, enflurane, and isoflurane do not effect the basal or agonist-stimulated activity of partially isolated soluble and particulate guanyl cyclases of rat brain. Anesthesiology. 1995;83:395–404
  30. Zuo Z, DeVente J, Johns RA. Halothane and isoflurane dose-dependently inhibit the cyclic GMP increase caused by N-methyl-d-aspartate in rat cerebellum: novel localization and quantitation by in vitro autoradiography. Neuroscience. 1996;74:1069–1075
  31. Morgan WW, Bermudez J, Chang X. The relative potency of pentobarbital in suppressing the kainic acid-or N-methyl-d-aspartate acid-induced enhancement of cGMP in cerebellar cells. European Journal of Pharmacology. 1991;204:335–338
  32. Terasako K, Nakamura K, Miyawaki I, et al. Inhibitory effects of anesthetics on cyclic guanosine monophosphate (cGMP) accumulation in rat cerebral cells. Anesthesia Analgesia. 1994;78:823–830
  33. Moruzzi G, Magoun H. Brain stem reticular formation and activation of the electroencephalogram. Electroencephalography and Clinical Neurophysiology. 1949;1:455–473
  34. Svenningsson P, Tzavara ET, Carruthers R, et al. Diverse psychotomimetics act through a common signaling pathway. Science. 2003;302:1412–1415
  35. Vollenweider G. Recent advances and concepts in the search for biological correlates of hallucinogen-induced altered states of consciousness. Heffter Review of Psychedelic Research. 1991;1:21–32
  36. Milner P. A model for visual shape recognition. Psychological Review. 1974;81:521–535
  37. Singer W, Gray CM. Visual feature integration and the temporal correlation hypotheses. Annual Review or Neuroscience. 1995;18:535–586
  38. Volgushev M, Christiakova M, Singer W. Modification of discharge patterns of neocortical neurons by induced oscillations of the membrane potential. Neuroscience. 1998;83:15–25
  39. Singer W. Consciousness and the structure of neuronal representations. Philosophical Transaction of the Royal Society of London, B. Biological Science. 1998;353:1829–1840
  40. Lisman JE, Fellous J-M, Wang X-J. A role for NMDA receptor channels in working memory. Nature Neuroscience. 1998;1:273–275
  41. Wang X-J. Synaptic basis of cortical persistent activity: the importance of NMDA receptors to working memory. Journal of Neuroscience. 1999;19:9587–9603

PII: S1521-6896(05)00066-2

doi: 10.1016/j.bpa.2005.08.009

Best Practice & Research Clinical Anaesthesiology
Volume 20, Issue 1 , Pages 11-22 , March 2006